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Symbol
Name
ID

Vps35
VPS35 retromer complex component
MGI:1890467

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Hyposmia

Spasticity

Bradykinesia

Parkinsonism

Tremor

Resting tremor

Depression

Anxiety

Panic attack

Hallucinations

Apathy

Reduced social reciprocity

Impulsivity

Agitation

Restless legs

Cognitive impairment

Dementia

Frontal lobe dementia

Short attention span

Insomnia

Hyperreflexia

Akinesia

Dyskinesia

Dystonia

Gait imbalance

Postural instability

Abnormal autonomic nervous system physiology

Disease(s) Associated with VPS35

Parkinson's disease

Parkinson's disease 17

Mouse Phenotypes		nervous system phenotype	microgliosis	abnormal substantia nigra pars compacta morphology	astrocytosis	abnormal dopaminergic neuron morphology	decreased dopaminergic neuron number	loss of dopaminergic neurons	abnormal axon morphology	alpha-synuclein inclusion body	neurodegeneration
Availability	Mouse Genotype	nervous system phenotype	microgliosis	abnormal substantia nigra pars compacta morphology	astrocytosis	abnormal dopaminergic neuron morphology	decreased dopaminergic neuron number	loss of dopaminergic neurons	abnormal axon morphology	alpha-synuclein inclusion body	neurodegeneration
	Vps35^tm1.1Mjff/Vps35^tm1.1Mjff
	Vps35^{Gt(RRK261)Byg}/Vps35⁺
	Vps35^tm1.1Hlw/Vps35⁺	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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